Preheat the oven to 250°F (120°C).

Spread the pretzels out on a large baking sheet lined with parchment paper.

In a mixing bowl, combine the melted butter, hot sauce, garlic powder, paprika, cayenne pepper, and ranch seasoning until smooth.

Drizzle the seasoning mixture over the pretzels and toss gently to coat evenly.

Bake for 45 minutes, stirring every 15 minutes to toast evenly.

Let the pretzels cool completely before storing in an airtight container.